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| Home > Publications database > Analysis of blood-based DNA methylation scores reveals associations with shared cohabitation duration in cohabiting pairs. |
| Home > Publications database > Analysis of blood-based DNA methylation scores reveals associations with shared cohabitation duration in cohabiting pairs. |
| Journal Article | DKFZ-2026-00507 |
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2026
Oxford Univ. Pr.
Oxford [u.a.]
Abstract: Individuals who share their environment for long periods of time, i.e., spouses, are likely to share behaviours and exposures, and longer spouse-pair cohabitation durations have been suggested to increase methylation pattern similarity on a methylome-wide scale. Risk scores and aging clocks based on blood DNA methylation use subsets of the methylome that share functional associations with disease and phenotype outcomes to estimate exposure and disease specific epigenetic effects. By using the CpG sites contained within methylation risk scores and aging clocks, it is possible to examine functionally-linked methylation patterns of long-term shared exposure effects. In a population cohort of paired adults, we observed that methylation disease and phenotype risk scores show no significant correlation between partners, and neither do aging clocks after adjustment for age, which is already correlated in pairs. We also did not find evidence of absolute difference in scores being significantly associated with cohabitation duration. However, when we examined the correlation in normalised methylation values between partners we observed that correlations were higher in pairs with longer cohabitation durations for many, but not all, functionally-linked CpG sets. This supports the hypothesis that shared cohabitation's association with methylome-wide similarity in pairs is the result of many shared exposures, not a generic effect of cohabitation. Further research is required to establish the precise exposure-methylation links implicated.
Keyword(s): aging ; clock ; epigenetics ; similarity
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