guest ::
| Home > Publications database > Steady-state mobilization with on-demand plerixafor after CD38 antibody-based induction in multiple myeloma patients. |
| Home > Publications database > Steady-state mobilization with on-demand plerixafor after CD38 antibody-based induction in multiple myeloma patients. |
| Journal Article | DKFZ-2026-00684 |
; ; ; ; ; ; ; ; ; ; ; ; ;
2026
Wiley-Blackwell
Oxford [u.a.]
Abstract: High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) remains the standard of care for fit patients with newly diagnosed multiple myeloma (MM). The increasing use of CD38 antibody-based quadruplet induction regimens such as daratumumab-VTd (Dara-VTd) has raised concerns regarding impaired stem cell mobilization.We conducted a retrospective single-center analysis comparing steady-state stem cell mobilization after Dara-VTd versus bortezomib-cyclophosphamide-dexamethasone (VCd) induction. Mobilization kinetics, plerixafor use, and CD34+ collection outcomes were evaluated. CD34+ counts prior to first apheresis were adjusted for plerixafor use (adjCD34+). Multivariate logistic regression was performed to identify predictors of mobilization success.Among 153 patients, 85 received Dara-VTd and 68 received VCd. Despite significantly deeper responses after Dara-VTd (≥VGPR 81% vs. 42%; p < .01), these patients showed lower adjCD34+ counts prior to first apheresis (16 vs. 50/μL; p < .01) and required plerixafor more frequently (64% vs. 15%; p < .01). Nevertheless, cumulative CD34+ yields were comparable between Dara-VTd and VCd (6.4 vs. 6.0 × 106 CD34+ cells/kg; p = .15), and target yields were achieved in the majority of patients proceeding to apheresis (90% vs. 94%). Dara-VTd induction, prior radiation, and high tumor burden were identified as independent negative predictors of mobilization success.Although Dara-VTd induction is associated with impaired mobilization kinetics, successful steady-state mobilization remains feasible. On-demand plerixafor use overcomes mobilization deficits, supporting this approach in patients receiving CD38-based quadruplet induction therapy. Furthermore, follow-up analysis of stem cell graft utilization demonstrates a high proportion of collected but unused stem cell grafts in both cohorts.
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection
|
The record appears in these collections: |
