guest ::
| Home > Publications database > Cyclotron production of 67Ga using electroplated 68Zn targets on gold and gold-coated aluminum backings. |
| Home > Publications database > Cyclotron production of 67Ga using electroplated 68Zn targets on gold and gold-coated aluminum backings. |
| Journal Article | DKFZ-2026-00796 |
; ; ; ; ; ;
2026
Elsevier Science
Amsterdam [u.a.]
Abstract: Gallium-67 remains a relevant radionuclide for single-photon emission computed tomography (SPECT) and radiopharmaceutical development as a longer-lived 68Ga surrogate. In this work, the use of gold and gold-coated aluminum backings was evaluated for the cyclotron-based production of this radionuclide via the 68Zn(p,2n)67Ga nuclear reaction. Using such targets, activities of 2.1-2.6 GBq were achieved for irradiation times of 120-150 min at end of proton bombardment, corresponding to saturation yields of 2900-3800 MBq/μA. A radiochemical separation based on two chromatographic resins, combined with an anion-exchange step, was evaluated to recover over 70 % of the [67Ga]GaCl3 in 0.5 mL. Radionuclidic purity exceeded 98 % at end of purification and increased with time due to the decay of the shorter-lived 66Ga. Trace metal analysis and test radiolabelling with NOTA confirmed apparent molar activities between 13 and 70 GBq/μmol, depending on the purification scheme. The suitability of the produced [67Ga]GaCl3 for radiopharmaceutical applications was further validated by the successful synthesis of six 67Ga-labelled radioligands, namely [67Ga]Ga-PSMA-11, [67Ga]Ga-PSMA-I&T, [67Ga]Ga-FAPI-46, [67Ga]Ga-FAP-2286, [67Ga]Ga-DOTA-TATE, and [67Ga]Ga-DPI-4452. Gold-coated aluminum backings demonstrated good irradiation stability, although further optimization is required to improve reusability.
Keyword(s): Cyclotron-based radionuclide production ; Gallium-67 ; SPECT radionuclide ; Targetry ; radiochemical separation
; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz
; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection
|
The record appears in these collections: |
