Journal Article

DKFZ-2026-01529

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Immune Markers and Risk of Pancreatic Cancer in the European EPIC Cohort.

Katzke, V. (First author)DKFZ* ; Chen, Y. (First author)DKFZ* ; Dutta, S.DKFZ* ; Canzian, F.DKFZ* ; Andersen, J. L. M. ; Rostgaard-Hansen, A. L. ; Bouteille, L. ; Rebours, V. ; Truong, T. ; Schulze, M. B. ; Bendinelli, B. ; Pala, V. ; Simeon, V. ; Tumino, R. ; Sacerdote, C. ; Vermeulen, R. ; Kolijn, P. M. ; Elias, S. G. ; Crous-Bou, M. ; Sánchez, M.-J. ; Jimenez-Zabala, A. ; Huerta, J. M. ; Guevara, M. ; Wareham, N. ; Breeur, M. ; Johansson, M. ; Yarmolinsky, J. ; Campa, D. ; Kaaks, R. (Last author)DKFZ*

2026
Wiley-Liss Bognor Regis

Abstract: The immune system is a major driver in pancreatic cancer development. Several prospective cohort studies have found associations for single immune system-derived proteins such as IL6 or CRP, but results are inconclusive, and Omics-based research is scarce. Hence, we aimed to investigate associations of a comprehensive protein panel with the risk of pancreatic cancer. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, 92 immune proteins were measured in baseline blood samples of 406 incident pancreatic cancer cases and 406 sex- and age-matched controls, using the Olink Immuno-Oncology panel. Multivariable adjusted conditional logistic regression was used to estimate odds ratios (OR, 95% CI) for protein levels in association with pancreatic cancer risk. Eight biomarkers were associated with pancreatic cancer risk (MMP12, LAMP3, CD28, IL-6, IL-12, FASLG, PD-L2, and PDCD1) but only MMP12 was significantly associated after multivariable adjustments for confounders and the seven proteins, with OR = 1.56 (95% CI: 1.20-2.03) for a doubling in protein concentration. After correction for multiple testing, none of the proteins were associated with risk. Restricting analyses to cases diagnosed within the first 4 years and 4-8 years after recruitment resulted in OR of 1.89 (95% CI: 1.28-2.80) and 1.37 (95% CI: 1.01-1.86) for MMP12, respectively. Higher levels of MMP12 were associated with pancreatic cancer risk specifically in those diagnosed shortly after recruitment, while other immune-related factors were not associated with risk. Further cohort studies are needed to confirm our initial findings.

Keyword(s): EPIC ; Olink ; cohort ; immune markers ; immune‐oncology ; inflammation ; proteins

Note: #EA:C020#EA:C180#LA:C020#

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Contributing Institute(s):

1. Epidemiologie von Krebs (C020)
2. Krebsepidemiologie (C180)
3. Genomische Epidemiologie (C055)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2026

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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