Journal Article

DKFZ-2026-01641

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Targeted Radiation, Unintended Evolution.

Lückerath, K.DKFZ* ; Hadaschik, B.DKFZ* ; Herrmann, K.DKFZ* ; von Amsberg, G.

2026
AACR Philadelphia, Pa. [u.a.]

Abstract: Radioligand therapy exemplifies precision oncology, yet its consequences remain incompletely understood. A recent article shows that [177Lu]Lu-PSMA promotes emergence and expansion of clonal hematopoiesis enriched for DNA damage response gene mutations, reframing bone marrow effects as treatment-emergent clonal selection rather than collateral toxicity and informing biology-guided patient monitoring and theranostics. See related article by Munzur et al., p. 2644.

Keyword(s): Humans (MeSH) ; Neoplasms: radiotherapy (MeSH) ; Neoplasms: genetics (MeSH) ; DNA Damage (MeSH) ; Clonal Hematopoiesis: radiation effects (MeSH) ; Animals (MeSH)

Note: #DKTKZFB9#

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Essen/Düsseldorf (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2026

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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