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| Home > Publications database > Helicobacter pylori, herpes simplex virus-1, varicella-zoster virus, and dementia risk. |
| Journal Article | DKFZ-2026-01764 |
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2026
Wiley
Hoboken, NJ
Abstract: Helicobacter pylori (H. pylori), herpes simplex-1 (HSV-1), and varicella-zoster virus (VZV) could increase dementia risk; however, evidence from large cohorts with long-term follow-up is scarce.Multivariable-adjusted Cox proportional-hazards models were used to investigate the association between H. pylori, HSV-1, and VZV seropositivity and dementia risk over 24 years in 8550 participants from the European Prospective Investigation into Cancer in Norfolk study in the United Kingdom.H. pylori (hazard ratio [HR] = 1.24, 95% confidence interval [CI]: 1.09 to 1.41), but not HSV-1 (HR = 1.03, 95% CI: 0.91 to 1.18) or VZV (HR = 1.01, 95% CI: 0.86 to 1.19), was associated with dementia risk. The H. pylori-dementia association remained robust among incident cases >15 years after blood draw (HR = 1.26, 95% CI: 1.06 to 1.48). Seropositive tertiles of the H. pylori antibodies CagA (p = 0.007) and GroEL (p = 0.001) demonstrated significant trends with dementia risk.H. pylori may represent a novel dementia prevention target, although early-life socioeconomic factors might confound the association.
Keyword(s): European Prospective Investigation into Cancer in Norfolk (EPIC‐Norfolk) ; Helicobacter pylori ; dementia ; herpes simplex‐1 ; longitudinal ; varicella‐zoster virus
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