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| Home > Publications database > MANGO‐“Fruitcage”: A Conditional Photocage Utilizing a Fluorescence Light‐Up Aptamer |
| Home > Publications database > MANGO‐“Fruitcage”: A Conditional Photocage Utilizing a Fluorescence Light‐Up Aptamer |
| Journal Article | DKFZ-2026-01807 |
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2026
Wiley-VCH
Weinheim
Abstract: Photolabile protecting groups (PPGs) offer light-controlled molecular activation, but improving their photolysis quantum yield (QY) remains a challenge. Here, we present a proof of concept for an approach that we call "fruitcaging" which pertains to new conditionally activatable photocages. We show that a photocleavable thiazole orange 1 derivative (TO1-cage) alone has a QY below 0.1%, rendering it nearly inactive. However, in the presence of the fluorescence light-up aptamer (FLAP) Mango, the fluorescence emission increased 180-fold, and the photocleavage reaction 14-fold. Femtosecond time resolved experiments revealed a drastically prolonged excited state lifetime of the TO1-cage upon binding to the Mango-aptamer, which facilitates the cleavage reaction and turned an inactive photocage to an active aptamer-photocage system-the "fruitcage". This strategy offers detailed insights in the engineering of the excited state dynamics of a TO1-based PPG and therefore presents a new tool for efficient conditionally activated PPG for a variety of applications in the field of photochemistry.
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