Journal Article (Review Article)

DKFZ-2026-01940

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Proteolysis Targeting Chimeric-Based Technology in Myeloma and Lymphoma.

Tigu, A. B. ; Ivancuta, A. ; Tomuleasa, C. ; Nistor, M. ; Kegyes, D. ; Cenariu, D. ; Munteanu, R. ; Buzoianu, A.-D. ; Einsele, H. ; Federico, M. ; Kobold, S.DKFZ* ; Gulei, D. ; Ciechanover, A.

2026
AACR Philadelphia, Pa.

Abstract: Proteolysis-targeting chimeras (PROTAC) leverage the ubiquitin-proteasome system to selectively degrade oncogenic proteins, including those previously seen as undruggable. Recent preclinical studies indicate that PROTACs may represent a novel therapeutic strategy in lymphoma and myeloma. Indeed, preclinically, PROTACs have shown high efficacy and remarkable selectivity, a favorable safety profile, and lower toxicity compared with conventional therapies. Their catalytic, reusable mechanism enables drug dosing and offers the perspective of long-term low-dose treatment. PROTACs have demonstrated their ability to overcome drug resistance by targeting and degrading overexpressed or mutant proteins that are responsible for refractory disease. This review aims to offer a comprehensive evaluation of the currently existing PROTACs that have been tested in lymphoma and myeloma to highlight the need for drug optimization and further translational research that could translate PROTACs to clinical trials.

Keyword(s): Humans (MeSH) ; Lymphoma: drug therapy (MeSH) ; Lymphoma: metabolism (MeSH) ; Lymphoma: pathology (MeSH) ; Proteolysis Targeting Chimera (MeSH) ; Multiple Myeloma: drug therapy (MeSH) ; Multiple Myeloma: metabolism (MeSH) ; Multiple Myeloma: pathology (MeSH) ; Animals (MeSH) ; Proteolysis (MeSH) ; Antineoplastic Agents: therapeutic use (MeSH) ; Antineoplastic Agents: pharmacology (MeSH) ; Proteasome Endopeptidase Complex: metabolism (MeSH) ; Molecular Targeted Therapy (MeSH) ; Proteolysis Targeting Chimera ; Antineoplastic Agents ; Proteasome Endopeptidase Complex

Note: #DKTKZFB9#

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Contributing Institute(s):

1. DKTK Koordinierungsstelle München (MU01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2026

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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