Journal Article (Letter)

DKFZ-2026-02453

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Tie1 ectodomain cleavage governs vascular responses to inflammatory stimulation but is dispensable for angiogenic signaling.

Kamiyama, M. (First author)DKFZ* ; Shi, J. (First author)DKFZ* ; Rinck, L. ; Lin, Y. ; Mao, Y. ; Zhang, X.DKFZ* ; Pari, A. A. A.DKFZ* ; Preuss, S. F.DKFZ* ; Hoffarth, M. ; Hofsetz, G. ; Di, Y. ; Zahran, A. ; Spegg, C.DKFZ* ; Riedel, M.DKFZ* ; Inverso, D.DKFZ* ; Ola, R. ; Hu, J. ; Alitalo, K. ; Augustin, H. (Last author)DKFZ* ; Singhal, M.

2026
ASCJ Ann Arbor, Mich.

Abstract: Ectodomain cleavage of the vascular receptor Tie1 distinguishes the inflammatory from the angiogenic functions of Angiopoietin-Tie signaling, mechanistically uncoupling two fundamental vascular programs.

Keyword(s): Signal Transduction (MeSH) ; Humans (MeSH) ; Animals (MeSH) ; Inflammation: metabolism (MeSH) ; Inflammation: genetics (MeSH) ; Inflammation: pathology (MeSH) ; Angiogenesis (MeSH) ; Receptor, TIE-1: metabolism (MeSH) ; Receptor, TIE-1: genetics (MeSH) ; Neovascularization, Physiologic (MeSH) ; Mice (MeSH) ; Protein Domains (MeSH) ; Angiogenesis ; Inflammation ; Signal transduction ; Vascular biology ; Receptor, TIE-1

Note: #EA:A190#LA:A190#

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Contributing Institute(s):

1. Vaskuläre Onkologie und Metastasierung (A190)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2026

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Database coverage:
; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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