Journal Article

DKFZ-2026-02631

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lung transplantation after allogeneic hematopoietic stem cell transplantation: a study from the Transplant Complications Working Party of the EBMT.

Montoro, J. ; Bos, S. ; Peczynski, C. ; Ambron, P. ; Badoglio, M. ; Vos, R. ; Gedde-Dahl, T. ; Holm, A. ; Aljurf, M. ; Rabitsch, W. ; Ma, D. ; Havryk, A. ; Rajasekariah, H. ; Sanz, J. ; Bataller, A. ; Reig, J. P. ; Schetelig, J. ; Kolditz, M. ; Iori, A. P. ; Koenecke, C. ; Gotlieb, J. ; Bellido, M. ; Gan, T. ; Zeiser, R. ; Rovira, M. ; Figuera, A. ; Redjoul, R. ; Schlemmer, F. ; Moiseev, I. ; Peric, Z. ; Penack, O.DKFZ* ; Schoemans, H.

2026
Springer Nature London

Abstract: Late-onset non-infectious pulmonary complications (LONIPCs) are severe late complications after allogeneic hematopoietic cell transplantation (HCT), associated with high morbidity and mortality. Lung transplantation (LT) may offer a survival benefit, but is infrequently performed due to concerns regarding outcomes. We conducted a retrospective multicenter study of adult patients who underwent LT for LONIPCs after HCT between 2000 and 2019. Thirty-one centers contributed clinical data. Seventy-one patients were included (59% male). Median age at HCT was 31 years. Acute leukemia was the most common HCT indication (62%). Peripheral blood was the main stem cell source (87%), and related donors accounted for 54% of cases. All patients developed chronic graft-versus-host disease, severe in 78%, with lung involvement in 88%. Bronchiolitis obliterans syndrome was the primary indication for LT (78%), occurring a median of 55 months after HCT. Bilateral LT was performed in 93% of cases. Overall survival at 1 and 5 years after LT was 87% and 71%, respectively. HLA-mismatched donor transplantation and corticosteroid use at LT were associated with inferior survival. LT is a feasible option for selected patients with end-stage LONIPCs, with long-term survival comparable to that reported for LT performed for other indications.

Note: #DKTKZFB9# / #NCTZFB9# / epub

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Berlin (BE01)
2. Koordinierungsstelle NCT Berlin (BR01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2026

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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