Journal Article

DKFZ-2026-02727

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Pre-diagnostic blood selenium status and mortality among gastric cancer patients from Western European populations.

Li, J. ; Jenab, M. ; Schomburg, L. ; Park, J. Y. ; Abedi-Ardekani, B. ; Agudo, A. ; Dahm, C. C. ; Eriksen, A. K. ; Tjønneland, A. ; Rothwell, J. ; Cadeau, C. ; Kaaks, R.DKFZ* ; Katzke, V.DKFZ* ; Schulze, M. B. ; Masala, G. ; Pala, V. ; Pasanisi, F. ; Tumino, R. ; Sacerdote, C. ; Boone, A. L. D. ; Jakszyn, P. G. ; Sánchez, M.-J. ; Amiano, P. ; Colorado-Yohar, S. M. ; Guevara, M. ; Wallner, B. ; Rutegård, M. ; Weiderpass, E. ; Heath, A. K. ; Hughes, D. J. ; Fedirko, V.

2026
Elsevier Amsterdam [u.a.]

Abstract: Gastric cancer remains one of the most lethal malignant tumors worldwide. Whether selenium status before diagnosis is associated with survival following gastric cancer diagnosis remains unclear.Among 653 patients diagnosed with gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we examined associations of pre-diagnostic plasma selenium (Se), selenoprotein P (SELENOP) concentrations, and glutathione peroxidase 3 (GPX3) activity with gastric cancer-specific and overall mortality using multivariable Cox proportional hazards models.Blood samples were collected an average of 8.8 years before diagnosis. During follow-up, 483 patients died, including 359 from gastric cancer. The median observed time from diagnosis to death or censoring was 1.3 years. Multivariable-adjusted HRs (95% CIs) per one-SD increase in Se, SELENOP, and GPX3 were 0.95 (0.83-1.09), 0.94 (0.82-1.07), and 1.00 (0.88-1.14), respectively, for gastric cancer-specific mortality, and 0.97 (0.87-1.09), 0.94 (0.84-1.05), and 0.98 (0.87-1.09) for overall mortality.Pre-diagnostic biomarkers of selenium status were not clearly associated with gastric cancer-specific or overall mortality in this cohort. Further studies in populations with different selenium exposure distributions are needed to assess the generalizability of these findings and to replicate exploratory subgroup results.

Keyword(s): Gastric cancer ; Mortality ; Prospective cohort ; Selenium

Note: epub

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Contributing Institute(s):

1. Erimitus im DKFZ (Z999)
2. Krebsepidemiologie (C180)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2026

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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