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| Home > Publications database > Definition of joint biomarker signatures for patients with locally advanced HNSCC treated by postoperative radiochemotherapy – A multicentre study of the DKTK-ROG |
| Home > Publications database > Definition of joint biomarker signatures for patients with locally advanced HNSCC treated by postoperative radiochemotherapy – A multicentre study of the DKTK-ROG |
| Journal Article | DKFZ-2026-02740 |
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2027
Elsevier
Amsterdam
Abstract: Several prognostic biomarkers have previously been identified for patients with locally advanced head and necksquamous cell carcinoma (HNSCC) treated with postoperative radiochemotherapy (PORT-C) in a comprehensivebiomarker program conducted by the German Cancer Consortium - Radiation Oncology Group (DKTK-ROG).Here, we combined these biomarkers into composite signatures for loco-regional control (LRC) and overallsurvival (OS) in 143 patients with HPV16 DNA-negative tumours. The C-indices for baseline, extended and datadriven signatures were 0.77, 0.93 and 0.94 for LRC and 0.69, 0.83 and 0.82 for OS, respectively. These predefined models will next be tested in the prospective HNpradBio ¨ validation cohort, which has completedrecruitment and data collection.
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