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| Home > Publications database > Systemic therapy of pancreatic cancer: state-of-the-art and personalized treatment options. [Systemtherapie des Pankreaskarzinoms: aktueller Standard und personalisierte Therapieansätze]. |
| Home > Publications database > Systemic therapy of pancreatic cancer: state-of-the-art and personalized treatment options. [Systemtherapie des Pankreaskarzinoms: aktueller Standard und personalisierte Therapieansätze]. |
| Journal Article | DKFZ-2026-02754 |
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2026
Springer Medizin
New York
Abstract: Pancreatic ductal adenocarcinoma (PDAC) represents an oncological challenge. Late diagnosis—often in a metastatic stage—together with the rapid development of treatment resistance compromises therapeutic success and ultimately patient survival. Over the past decades, combined chemotherapy has become the backbone of modern systemic treatment of pancreatic cancer in metastatic and adjuvant settings. Identification of molecular subgroups has led to improvement for selected patients due to expansion of the treatment spectrum to include targeted therapies. The development of RAS-directed therapies changes pancreatic cancer treatment fundamentally, and the development of new combination strategies will have an important role in the future.
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