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| Home > Publications database > Selenoprotein P and type 2 diabetes risk in a large cohort of older German adults. |
| Journal Article | DKFZ-2026-02795 |
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2026
Elsevier
Amsterdam [u.a.]
Abstract: A previous meta-analysis reported an increased type 2 diabetes (T2D) risk at high blood selenium levels but included few prospective cohorts. Here, we assessed the long-term associations of serum SELENOP concentrations and incident T2D in a large cohort.Serum SELENOP concentrations were measured at baseline and 5-year follow-up in 6529 participants aged 50-74 years in the German ESTHER study. Multivariable Cox models were performed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident T2D across quintiles (Q) of SELENOP concentrations.During a median follow-up of 11.5 years (interquartile range, 7.1-16.7 years), 1235 participants developed T2D. No statistically significant association between time-dependently modelled SELENOP and T2D risk was observed (HR [95%CI] for Q5 vs. Q1, 1.08 [0.89-1.30]). SELENOP concentrations decreased on average by 0.90 mg/L from baseline to 5-year follow-up. For those 80% of the population, for whom SELENOP decreased by less than 1.83 mg/L, a statistically significant 22% lower T2D risk was observed compared to those 20% with a larger SELENOP decrease (HR [95%CI]: 0.78 [0.62-0.98]). Results were consistent across subgroups defined by sex, age, BMI, smoking status, physical activity level, prediabetes, oxidative stress, inflammatory status, and vitamin D status.This large prospective cohort study found no increased long-term risk of T2D among older adults residing in Germany with time-dependently modelled SELENOP concentrations. However, although a decrease in SELENOP with ageing is normal, the 20% of the population with the greatest decline in serum SELENOP concentrations showed an increased T2D risk.
Keyword(s): Cohort study ; Diabetes mellitus ; Selenium ; Selenoprotein P ; Type 2
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