A013
NWG Tumorprogression und Metastasierung
Also known as:A013; Biomarkeridentifizierung; NWG Tumorprogression und Metastisierung
| ID | I:(DE-He78)A013-20160331 |
Recent Publications
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Journal Article
Vaquero-Siguero, N. (First author)DKFZ* ; Georgakopoulos, N. (First author)DKFZ* ; Puschhof, M. (First author)DKFZ* ; Chiotakakos, I.DKFZ* ; Meier, J.DKFZ* ; Fey, S. K.DKFZ* ; Diamante, G.DKFZ* ; Mastel, M.DKFZ* ; Guiseris-Martinez, A.DKFZ* ; Belthier, G. ; Schleußner, N.DKFZ* ; Volk, J.DKFZ* ; Artmann, C.DKFZ* ; Lim, B.DKFZ* ; Koschny, R. ; Wehling, C. ; Ouyang, K.DKFZ* ; Günther, M. ; Kuss, S. ; Hoffmeister, P. ; Mall, M.DKFZ* ; Neumann, J. ; Ormanns, S. ; Schneider, M. ; Schmidt, T. ; Puschhof, J.DKFZ* ; Trumpp, A.DKFZ* ; van Rheenen, J. ; Saez-Rodriguez, J. ; Köhler, B. C. ; Jackstadt, R.-F. (Last author)DKFZ*
TROP2 targeting reveals therapy-driven cell state dynamics in colorectal cancer.
Nature nn, nn (2026) [10.1038/s41586-026-10705-2]2026
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Journal Article (Review Article)
Nader, L. (First author)DKFZ* ; Hoffmeister-Wittmann, P.DKFZ* ; Haag, G. M.DKFZ* ; Jackstadt, R.DKFZ* ; Köhler, B. C.DKFZ*
Sacituzumab govitecan in colorectal cancer: clinical evidence and future directions.
Future oncology 22(13), 1581-1591 (2026) [10.1080/14796694.2026.2673807]2026
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Journal Article
Venkatachalam, N. ; Wang, L. ; Muthukumarana, N. ; Ihnatko, R.DKFZ* ; Krijgsveld, J.DKFZ* ; Skabkina, O. ; Leipertz, A. ; Chen, Y. ; Sui, P.DKFZ* ; Zheng, Q. ; Tong, P. ; Liu, X. ; Descot, A. ; Schewe, M. ; Diamante, G.DKFZ* ; Jackstadt, R.DKFZ* ; Brochhausen, C. ; Betge, J.DKFZ* ; Boonekamp, K.DKFZ* ; Boutros, M.DKFZ* ; Stoecklin, G. ; Ebert, M. ; Schott, J. ; Zhan, T.
Ras-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis.
Cell communication and signaling 24(1), 324 (2026) [10.1186/s12964-026-02963-4]2026
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Journal Article
Madi, A. A. M. (First author)DKFZ* ; Shi, H. ; Su, M. ; Mady, A. ; Lv, B. ; Wang, H. ; Yang, B. ; Yan, Z. ; Jin, X. ; Wu, L. ; Lv, M. ; Hering, M.DKFZ* ; Ma, S. ; Mieg, A.DKFZ* ; Zettl, F.DKFZ* ; Yan, X.DKFZ* ; Mohr, K.DKFZ* ; Knabe, N.DKFZ* ; Poschet, G. ; Richter, K.DKFZ* ; Schleußner, N.DKFZ* ; Jackstadt, R.-F.DKFZ* ; Loges, S.DKFZ* ; Papavasiliou, F.DKFZ* ; Wang, X. ; Wu, J. ; Cui, G. (Last author)DKFZ*
DGAT1 mediates sex-specific CD8+ T cell antitumour responses.
Nature metabolism 8, 685–703 (2026) [10.1038/s42255-026-01462-7]2026
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Journal Article
White, M. ; Mills, M. L. ; Millett, L. M. ; Gilroy, K. ; Hong, Y. ; Zeiger, L. B. ; Simpson, R. J. ; Corry, S. M. ; Ligeza, A. ; Lannagan, T. R. M. ; Susanti, S. ; Ridgway, R. A. ; Yazgili, A. S. ; Grzesiak, L. ; Amirkhah, R. ; Ford, C. A. ; Vlahov, N. ; Tovell, H. ; Officer-Jones, L. ; Ficken, C. ; Pennie, R. ; Najumudeen, A. K. ; Raven, A. ; Nasreddin, N. ; Chauhan, E. ; Papanastasiou, A. S. ; Nixon, C. ; Morrison, V. ; Jackstadt, R.-F.DKFZ* ; Graham, J. S. ; Miller, C. J. ; Ross, S. J. ; Barry, S. T. ; Pavet, V. ; Wilson, R. H. ; Le Quesne, J. ; Dunne, P. D. ; Tejpar, S. ; Leedham, S. ; Campbell, A. D. ; Sansom, O. J.
MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance.
Nature 650(8102), 748-758 (2026) [10.1038/s41586-025-09916-w]2026
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Journal Article
Gobits, R. ; Schleußner, N. (First author)DKFZ* ; Oliver, G. R. ; Rutenberg Schoenberg, M. ; de Jesus Domingues, A. M. ; Ramkumar, P. ; Suen, S. W. F. ; Koomen, M. P. M. ; Paolucci, F. ; Martens, K. ; Guiseris Martinez, A.DKFZ* ; Volk, J.DKFZ* ; Artmann, C.DKFZ* ; Mastel, M.DKFZ* ; Ouyang, K.DKFZ* ; Kloor, M. ; Bankaitis, E. D. ; Stoub, H. E. ; Puschhof, J.DKFZ* ; Brown, K. ; Pretzer, S. ; Nelson, D. A. ; Struminger, E. ; Zessin, A. ; Brown, A. ; Evans, C. ; Yetsko, D. ; Harrington, M. ; Salg, G. ; Schneider, M. ; Schmidt, T. ; Helman, E. ; Plenker, D. ; Barnett, C. ; Jones, R. T. ; Köhler, B. C.DKFZ* ; Driehuis, E. ; Jackstadt, R.-F. (Last author)DKFZ*
Functional Precision Medicine Using MicroOrganoSpheres for Treatment Response Prediction in Advanced Colorectal Cancer.
JCO precision oncology 10(10), e2500501 (2026) [10.1200/PO-25-00501]2026
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Journal Article
Wouters, V. M. ; Helderman, R. F. C. P. A. ; Cameron, K. ; van der Hooff, S. R. ; Torang, A. ; van den Bergh, S. ; Jackstadt, R.DKFZ* ; Sansom, O. J. ; van Neerven, S. M. ; Medema, J. P.
CDX2 downregulation regulates intrinsic WNT pathway activation, dictating metastasis in APC and CTNNB1 wildtype colorectal cancer.
Oncogene 44(25), 2091-2102 (2025) [10.1038/s41388-025-03365-5]2025
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Journal Article
Škapik, I. P. ; Giacomelli, C. ; Hahn, S. ; Deinlein, H. ; Gallant, P. ; Diebold, M. ; Biayna, J. ; Hendricks, A. ; Olimski, L. ; Otto, C. ; Kastner, C. ; Wolf, E. ; Schülein-Völk, C. ; Maurus, K. ; Rosenwald, A. ; Schleussner, N.DKFZ* ; Jackstadt, R.-F.DKFZ* ; Schlegel, N. ; Germer, C.-T. ; Bushell, M. ; Eilers, M. ; Schmidt, S. ; Wiegering, A.
Maintenance of p-eIF2α levels by the eIF2B complex is vital for colorectal cancer.
The EMBO journal 44, 2075 - 2105 (2025) [DOI:10.1038/s44318-025-00381-9]2025
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Journal Article
Torang, A. ; Kirov, A. B. ; Lammers, V. ; Cameron, K. ; Wouters, V. M. ; Jackstadt, R. F.DKFZ* ; Lannagan, T. R. M. ; de Jong, J. H. ; Koster, J. ; Sansom, O. ; Medema, J. P.
Enterocyte-like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability.
Nature Communications 16(1), 264 (2025) [10.1038/s41467-024-55574-3]2025
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Journal Article
Köhler, B. C.DKFZ* ; Haag, G. M. (First author)DKFZ* ; Le Cornet, L.DKFZ* ; Hoffmeister-Wittmann, P.DKFZ* ; Schmidt, M.DKFZ* ; Manjunath, A. ; Vaquero-Siguero, N.DKFZ* ; Jenzer, M. ; Gimmel, M. ; Stahler, A. ; Stein, A. ; Reichert, M. ; Kasper, S. ; Bitzer, M. ; Jäger, D.DKFZ* ; Springfeld, C. ; Weber, T. F.DKFZ* ; Fröhling, S.DKFZ* ; Steindorf, K.DKFZ* ; Trumpp, A.DKFZ* ; Schlenk, R. F. ; Jackstadt, R.-F. (Last author)DKFZ*
TROPHIT1—a randomized, open-label, multicenter, phase II/III trial of sacituzumab govitecan compared to standard of care in metastatic colorectal cancer patients
ESMO gastrointestinal oncology 7, 100118 (2025) [10.1016/j.esmogo.2024.100118]2025
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All known publications ...
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