Journal Article (Review Article)

DKFZ-2026-01280

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sacituzumab govitecan in colorectal cancer: clinical evidence and future directions.

Nader, L. (First author)DKFZ* ; Hoffmeister-Wittmann, P.DKFZ* ; Haag, G. M.DKFZ* ; Jackstadt, R.DKFZ* ; Köhler, B. C.DKFZ*

2026
Taylor & Francis London

Abstract: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide and continues to pose a significant global health burden. Despite therapeutic advances, the prognosis remains poor due to limited treatment options, resistance to therapy, and frequent metastasis. Standard treatment regimen primarily involve a combination of chemotherapy and biological agents. Sacituzumab govitecan (SG) is an antibody-drug conjugate (ADC) that targets trophoblast cell surface antigen 2 (TROP2). SG has demonstrated clinical efficacy and has been approved for the treatment of advanced triple-negative and hormone receptor-positive, HER2 negative breast cancers. TROP2 is broadly expressed in carcinomas and is associated with a poor prognosis, making it a promising therapeutic target. SG's success in breast cancer and broad expression in epithelial tumors has sparked interest in its potential applicability to CRC. This review provides an overview of SG's mechanism of action and current clinical applications, discussing its therapeutic potential in the context of CRC.

Keyword(s): ADC ; Colorectal cancer ; Sacituzumab govitecan ; clinical trial ; metastasis ; resistance ; targeted therapy

Note: DKFZ-ZMBH Alliance / #EA:A013# / #DKTKZFB26# / #NCTZFB26# / epub

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Contributing Institute(s):

1. NWG Tumorprogression und Metastasierung (A013)
2. Angewandte Tumor-Immunität (D120)
3. DKTK HD zentral (HD01)
4. Koordinierungsstelle NCT Heidelberg (HD02)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2026

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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