Journal Article

DKFZ-2018-00175

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

Klein, A. P. ; Wolpin, B. M. ; Risch, H. A. ; Stolzenberg-Solomon, R. Z. ; Mocci, E. ; Zhang, M. ; Canzian, F. ; Childs, E. J. ; Hoskins, J. W. ; Jermusyk, A. ; Zhong, J. ; Chen, F. ; Albanes, D. ; Andreotti, G. ; Arslan, A. A. ; Babic, A. ; Bamlet, W. R. ; Beane-Freeman, L. ; Berndt, S. I. ; Blackford, A. ; Borges, M. ; Borgida, A. ; Bracci, P. M. ; Brais, L. ; Brennan, P. ; Brenner, H.DKFZ* ; Bueno-de-Mesquita, B. ; Buring, J. ; Campa, D. ; Capurso, G. ; Cavestro, G. M. ; Chaffee, K. G. ; Chung, C. C. ; Cleary, S. ; Cotterchio, M. ; Dijk, F. ; Duell, E. J. ; Foretova, L. ; Fuchs, C. ; Funel, N. ; Gallinger, S. ; M Gaziano, J. M. ; Gazouli, M. ; Giles, G. G. ; Giovannucci, E. ; Goggins, M. ; Goodman, G. E. ; Goodman, P. J. ; Hackert, T. ; Haiman, C. ; Hartge, P. ; Hasan, M. ; Hegyi, P. ; Helzlsouer, K. J. ; Herman, J. ; Holcatova, I. ; Holly, E. A. ; Hoover, R. ; Hung, R. J. ; Jacobs, E. J. ; Jamroziak, K. ; Janout, V. ; Kaaks, R.DKFZ* ; Khaw, K.-T. ; Klein, E. A. ; Kogevinas, M. ; Kooperberg, C. ; Kulke, M. H. ; Kupcinskas, J. ; Kurtz, R. J. ; Laheru, D. ; Landi, S. ; Lawlor, R. T. ; Lee, I.-M. ; LeMarchand, L. ; Lu, L. ; Malats, N. ; Mambrini, A. ; Mannisto, S. ; Milne, R. L. ; Mohelníková-Duchoňová, B. ; Neale, R. E. ; Neoptolemos, J. P. ; Oberg, A. L. ; Olson, S. H. ; Orlow, I. ; Pasquali, C. ; Patel, A. V. ; Peters, U. ; Pezzilli, R. ; Porta, M. ; Real, F. X. ; Rothman, N. ; Scelo, G. ; Sesso, H. D. ; Severi, G. ; Shu, X.-O. ; Silverman, D. ; Smith, J. P. ; Soucek, P. ; Sund, M. ; Talar-Wojnarowska, R. ; Tavano, F. ; Thornquist, M. D. ; Tobias, G. S. ; Van Den Eeden, S. K. ; Vashist, Y. ; Visvanathan, K. ; Vodicka, P. ; Wactawski-Wende, J. ; Wang, Z. ; Wentzensen, N. ; White, E. ; Yu, H. ; Yu, K. ; Zeleniuch-Jacquotte, A. ; Zheng, W. ; Kraft, P. ; Li, D. ; Chanock, S. ; Obazee, O.DKFZ* ; Petersen, G. M. ; Amundadottir, L. T.

2018
Nature Publishing Group London

This record in other databases:  

Please use a persistent id in citations: doi:10.1038/s41467-018-02942-5

Abstract: In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.

---

Contributing Institute(s):

1. Klinische Epidemiologie und Alternsforschung (C070)
2. Präventive Onkologie (G110)
3. Epidemiologie von Krebserkrankungen (C020)
4. Genomische Epidemiologie (C055)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2018

---

Database coverage:
; ; ; BIOSIS Previews ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

---