Journal Article

DKFZ-2018-00177

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png High-resolution31P echo-planar spectroscopic imaging in vivo at 7T.

Korzowski, A. (First author)DKFZ* ; Bachert, P. (Last author)DKFZ*

2018
Wiley-Liss New York, NY [u.a.]

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Please use a persistent id in citations: doi:10.1002/mrm.26785

Abstract: Conventional31P chemical shift imaging is time-consuming and yields only limited spatial resolution. The purpose of this study was to demonstrate feasibility of31P echo-planar spectroscopic imaging (EPSI) in vivo at 7T.A 3D31P EPSI sequence with trapezoidal-shaped gradient pulses was implemented on a 7T MR scanner. To increase spectral width with reduced demand on gradient performance, a multishot approach was chosen. Acquisition weighting and31P-{1H} double resonance for nuclear Overhauser signal enhancement were applied to increase sensitivity.3D31P-{1H} EPSI data from model solution and from human calf muscle and brain were obtained from voxels with effective sizes of 4.1 to 16.2 cm3in measurement times of approximately 10 min. Individual spectra showed well-resolved resonances of endogenous31P-metabolites without artifacts. Volumetric high-resolution31P-metabolite maps in vivo showed metabolic heterogeneity of different tissues.In vivo31P EPSI at 7T yields high-quality metabolic images. The proposed multishot EPSI technique reduces the measurement times for acquisition of volumetric high-resolution maps of31P-metabolites or intracellular pH in human studies. Magn Reson Med 79:1251-1259, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

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Contributing Institute(s):

1. Medizinische Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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