Journal Article

DKFZ-2018-01293

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png 4D dose calculation for pencil beam scanning proton therapy of pancreatic cancer using repeated 4DMRI datasets.

Dolde, K. (First author)DKFZ* ; Naumann, P. ; Dávid, C.DKFZ* ; Gnirs, R.DKFZ* ; Kachelrieß, M.DKFZ* ; Lomax, A. J. ; Saito, N. ; Weber, D. C. ; Pfaffenberger, A.DKFZ* ; Zhang, Y.

2018
IOP Publ. Bristol

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Please use a persistent id in citations: doi:10.1088/1361-6560/aad43f

Abstract: 4D magnetic resonance imaging (4DMRI) has a high potential for pancreatic cancer treatments using proton therapy, by providing time-resolved volumetric images with a high soft-tissue contrast without exposing the patient to any additional imaging dose. In this study, we aim to show the feasibility of 4D treatment planning for pencil beam scanning (PBS) proton therapy of pancreatic cancer, based on five repeated 4DMRI datasets and 4D dose calculations (4DDC) for one pancreatic cancer patient. To investigate the dosimetric impacts of organ motion, deformation vector fields were extracted from 4DMRI, which were then used to warp a static CT of the patient, so as to generate synthetic 4DCT (4DCT-MRI). CTV motion amplitudes  <15 mm were observed for this patient. The results from 4DDC show pronounced interplay effects in the CTV with dose homogeneity d5/d95 and dose coverage v95 being 1.14 and 91%, respectively, after a single fraction of the treatment. An averaging effect was further observed when increasing the number of fractions. Motion effects can become less dominant and dose homogeneity d5/d95  =  1.03 and dose coverage v95  =  [Formula: see text] within the CTV can be achieved after 28 fractions. The observed inter-fractional organ and tumor motion variations underline the importance of 4D imaging before and during PBS proton therapy.

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Contributing Institute(s):

1. Medizinische Physik in der Strahlentherapie (E040)
2. Medizinische Physik in der Radiologie (E020)
3. Radiologie (E010)
4. Röntgenbildgebung und Computertomographie (E025)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; National-Konsortium ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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