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| Home > Publications database > Double quantum filtered 23 Na MRI with magic angle excitation of human skeletal muscle in the presence of B0 and B1 inhomogeneities. |
| Home > Publications database > Double quantum filtered 23 Na MRI with magic angle excitation of human skeletal muscle in the presence of B0 and B1 inhomogeneities. |
| Journal Article | DKFZ-2018-01580 |
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2018
Wiley
New York, NY
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Please use a persistent id in citations: doi:10.1002/nbm.4010
Abstract: Double quantum filtered 23 Na MRI with magic angle excitation (DQF-MA) can be used to selectively detect sodium ions located within anisotropic structures such as muscle fibers. It might therefore be a promising tool to analyze the microscopic environment of sodium ions, for example in the context of osmotically neutral sodium retention. However, DQF-MA imaging is challenging due to various signal dependences, on both measurement parameters and external influences. The aim of this work was to examine how B0 in combination with B1 inhomogeneities alter the DQF-MA signal intensity. We showed that, in the presence of B0 inhomogeneities, flip angle schemes with only one 54.7° pulse can be favorable compared with the classical 90°-54.7°-54.7° scheme. DQF-MA images of the human lower leg were acquired at B0 = 3 T with a nominal spatial resolution of 12 × 12 × 36 mm3 within an acquisition time of TAcq < 10 min, and compared with spin density weighted (DW), as well as triple quantum filtration (TQF) 23 Na images. We found mean normalized signal-to-noise ratios of TQF/DW = 13.7 ± 2.3% (tibialis anterior), 11.9 ± 2.3% (soleus) and 11.4 ± 2.2% (gastrocnemius medialis), as well as DQF-MA/DW = 4.7 ± 1.1% (tibialis anterior), 3.3 ± 0.73% (soleus) and 3.4 ± 0.6% (gastrocnemius medialis). These ratios might serve as additional measures in future clinical studies of sodium retention within human skeletal muscle. However, the influence of B0 and B1 inhomogeneities should be considered when interpreting DQF-MA images.
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