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| Home > Publications database > A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System. |
| Home > Publications database > A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System. |
| Journal Article | DKFZ-2019-01225 |
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2019
Elsevier
New York, NY
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Please use a persistent id in citations: doi:10.1016/j.neuron.2019.04.029
Abstract: Oxytocin (OT) release by axonal terminals onto the central nucleus of the amygdala exerts anxiolysis. To investigate which subpopulation of OT neurons contributes to this effect, we developed a novel method: virus-delivered genetic activity-induced tagging of cell ensembles (vGATE). With the vGATE method, we identified and permanently tagged a small subpopulation of OT cells, which, by optogenetic stimulation, strongly attenuated contextual fear-induced freezing, and pharmacogenetic silencing of tagged OT neurons impaired context-specific fear extinction, demonstrating that the tagged OT neurons are sufficient and necessary, respectively, to control contextual fear. Intriguingly, OT cell terminals of fear-experienced rats displayed enhanced glutamate release in the amygdala. Furthermore, rats exposed to another round of fear conditioning displayed 5-fold more activated magnocellular OT neurons in a novel environment than a familiar one, possibly for a generalized fear response. Thus, our results provide first evidence that hypothalamic OT neurons represent a fear memory engram.
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