Book/Journal Article

DKFZ-2019-01247

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Experimental Approaches to Investigate the Role of Helicase Acetylation in Regulating R-Loop Stability.

Song, C. (First author)DKFZ* ; Grummt, I. (Last author)DKFZ*

2019
[Springer] [Heidelberg]
ISBN: 978-3-662-58711-9 (print), 978-3-662-58712-6 (electronic)

This record in other databases:  

Please use a persistent id in citations: doi:10.1007/978-1-4939-9434-2_14

Abstract: R-loops are three-stranded nucleic acid structures composed of a DNA-RNA heteroduplex and a displaced single-stranded DNA. Although R-loops serve important roles in transcription and chromatin structure, they are also a major threat to genome stability. Cells prevent accumulation of genomic R-loops by mechanisms that remove these structures, such as ribonucleases which digest DNA-RNA hybrids and helicases which unwind R-loops. Here we describe methods to monitor resolvement of R-loops by the helicase DDX21 focussing on the impact of acetylation on helicase activity.

Note: Methods Mol Biol = 2626-0492 (import from CrossRef Book Series, PubMed, ) DKFZ-ZMBH Alliance

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Contributing Institute(s):

1. Novel small molecule inhibitors of cells (A030)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2019

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Database coverage:
; NCBI Molecular Biology Database ; SCOPUS

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