Journal Article

DKFZ-2019-01309

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Regulatory T cells sense effector T-cell activation through synchronized JunB expression.

Wu, J. (First author)DKFZ* ; Ma, S.DKFZ* ; Hotz-Wagenblatt, A.DKFZ* ; Angel, P.DKFZ* ; Mohr, K.DKFZ* ; Schlimbach, T.DKFZ* ; Schmitt, M. ; Cui, G. (Last author)DKFZ*

2019
Wiley Chichester

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Please use a persistent id in citations: doi:10.1002/1873-3468.13393

Abstract: To maintain immune tolerance, effector T-cell (Teff) responses must be checked by the regulatory T cells (Tregs) in time. It remains incompletely understood how Tregs sense real-time Teff activation. Here, we report that the AP-1 transcription factor JunB, which is induced in Teffs upon T-cell receptor (TCR) activation, is also increased in Tregs by TCR stimuli. Treg-specific deletion of Junb impairs Treg identity, causes uncontrolled inflammatory cytokine production by Teffs and leads to the T-box transcription factor T-bet-dependent spontaneous inflammation. Furthermore, JunB deficiency in Tregs unleashes antitumor Teff responses in a mouse model of melanoma. We conclude that JunB alarms Tregs of the emerging Teff activation and synchronizes immune regulation with the immune reaction in autoimmunity and cancer.

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Contributing Institute(s):

1. T-Zell-Metabolismus (D140)
2. T-Zell-Metabolismus (D192)
3. A100 Signaltransduktion/ Wachstumskontrolle (A100)

Research Program(s):

1. 314 - Tumor immunology (POF3-314) (POF3-314)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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