Journal Article

DKFZ-2020-00237

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lymphangiogenesis in a mouse model of renal transplant rejection extends life span of the recipients.

Pedersen, M. S. ; Müller, M. ; Rülicke, T. ; Leitner, N. ; Kain, R. ; Regele, H. ; Wang, S.DKFZ* ; Gröne, H.-J.DKFZ* ; Rong, S. ; Haller, H. ; Gueler, F. ; Rees, A. J. ; Kerjaschki, D.

2020
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.kint.2019.07.027

Abstract: Renal allograft rejection can be prevented by immunological tolerance, which may be associated with de novo formed lymphatic vessels in the donor kidney after transplantation in man. A suitable mouse model of renal allograft rejection in which lymphangiogenesis can be deliberately induced in the graft is critical for elucidating the mechanisms responsible for the association between attenuated transplant rejection and abundance of lymphatic vessels. Here we describe the development of a novel mouse model of rapid renal transplant rejection in which transgenic induction of lymphangiogenesis in the immune-incompatible graft greatly extends its survival time. Thus, our novel approach may facilitate exploitation of lymphangiogenesis in the grafted organ.

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Contributing Institute(s):

1. Zelluläre und Molekulare Pathologie (G130)

Research Program(s):

1. 319H - Addenda (POF3-319H) (POF3-319H)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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