Journal Article

DKFZ-2020-01149

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sodium relaxometry using 23 Na MR fingerprinting: A proof of concept.

Kratzer, F. (First author)DKFZ* ; Flassbeck, S.DKFZ* ; Nagel, A. M.DKFZ* ; Behl, N.DKFZ* ; Knowles, B. R.DKFZ* ; Bachert, P.DKFZ* ; Ladd, M. E.DKFZ* ; Schmitter, S. (Last author)DKFZ*

2020
Wiley-Liss New York, NY [u.a.]

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Please use a persistent id in citations: doi:10.1002/mrm.28316

Abstract: To evaluate the feasibility of 23 Na MR fingerprinting (MRF) for simultaneous quantification of T1 , T 2 l ∗ , T 2 s ∗ , T 2 ∗ in addition to ΔB0 .A framework for sodium relaxometry using MRF at 7T was developed, allowing simultaneous measurement of relaxation times and inhomogeneities in the static field. The technique distinguishes between bi- and monoexponential transverse relaxation and was validated in simulations with respect to the ground truth. In phantom measurements, a resolution of 2 × 2 × 12 mm3 was achieved within 1 h acquisition time, and the resulting parameter maps were compared to results from reference methods. Relaxation times in five healthy volunteers were measured with a resolution of 4 × 4 × 12 mm3 .Phantom experiments revealed an agreement between the relaxation times obtained via 23 Na-MRF and the reference methods. In white matter, a longitudinal relaxation constant of T1 = 38.9 ± 4.8 ms was found, while values of T 2 l ∗ = 29.2 ± 4.9 ms and T 2 s ∗ = 4.7 ± 1.2 ms were found for the long and short component of the transverse relaxation. In cerebrospinal fluid, T1 was 67.7 ± 6.3 ms and T 2 ∗ = 41.5 ± 3.4 ms.This work demonstrates the feasibility of 23 Na-MRF for relaxometry in sodium MRI in both phantom and in vivo studies. Simultaneous quantification of T1 , T 2 l ∗ , T 2 s ∗ , T 2 ∗ and ΔB0 was possible within a 1 h measurement time.

Note: 2020 Nov;84(5):2577-2591#EA:E020#LA:E020#

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Contributing Institute(s):

1. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2020

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