Book/Journal Article

DKFZ-2020-01440

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Analysis of RNA-DNA Triplex Structures In Vitro and In Vivo.

Postepska-Igielska, A. (First author)DKFZ* ; Blank-Giwojna, A.DKFZ* ; Grummt, I. (Last author)DKFZ*

2020
[Springer] [Heidelberg]
ISBN: 978-1-0716-0679-7 (print), 978-1-0716-0680-3 (electronic)

Abstract: RNA can bind within the major groove of purine-rich DNA via Hoogsteen base pairing and form a triple helical RNA-DNA structure that anchors the RNA to specific DNA sequences, thereby targeting RNA-associated regulatory proteins to distinct genomic sites. Here we present methods to analyze the potential of a given RNA to form triplexes in vitro and to validate these structures in vivo.

Note: DKFZ-ZMBH Alliance#EA:A030#LA:A030#

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Contributing Institute(s):

1. Novel small molecule inhibitors of cells (A030)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2020

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Database coverage:
; NCBI Molecular Biology Database ; SCOPUS

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