Home > Publications database > A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma-like features and Nuclear Clusters (DGONC). |
Journal Article | DKFZ-2020-02977 |
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2021
Wiley-Blackwell
Oxford [u.a.]
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Please use a persistent id in citations: doi:10.1111/nan.12680
Abstract: We read with interest Deng et al.'s recent manuscript concerning a newly molecularly defined glioneuronal CNS tumour entity, termed diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC)(1). DGONCs were identified by a distinctive methylation profile that segregated away from previously recognised molecular groups of CNS tumours. On further review, the authors describe DGONCs as a novel glioneuronal tumour with key neuropathological features including oligodendroglioma-like perinuclear halos and nuclear clusters.
Keyword(s): DNA methylation classification ; brain tumour ; glioneuronal tumour ; monosomy 14 ; paediatric
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