Journal Article

DKFZ-2021-00515

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Traveling Heads 2.0: Multicenter Reproducibility of Quantitative Imaging Methods at 7 Tesla.

Voelker, M. N. ; Kraff, O. ; Goerke, S.DKFZ* ; Laun, F. B. ; Hanspach, J. ; Pine, K. J. ; Ehses, P. ; Zaiss, M. ; Liebert, A. ; Straub, S.DKFZ* ; Eckstein, K. ; Robinson, S. ; Nagel, A. N. ; Stefanescu, M. R. ; Wollrab, A. ; Klix, S. ; Felder, J. ; Hock, M. ; Bosch, D. ; Weiskopf, N. ; Speck, O. ; Ladd, M. E.DKFZ* ; Quick, H. H.

2021
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.neuroimage.2021.117910

Abstract: This study evaluates inter-site and intra-site reproducibility at ten different 7 T sites for quantitative brain imaging.Two subjects - termed the 'traveling heads' - were imaged at ten different 7 T sites with a harmonized quantitative brain MR imaging protocol. In conjunction with the system calibration, MP2RAGE, QSM, CEST and multi-parametric mapping/relaxometry were examined.Quantitative measurements with MP2RAGE showed very high reproducibility across sites and subjects, and errors were in concordance with previous results and other field strengths. QSM had high inter-site reproducibility for relevant subcortical volumes. CEST imaging revealed systematic differences between the sites, but reproducibility was comparable to results in the literature. Relaxometry had also very high agreement between sites, but due to the high sensitivity, differences caused by different applications of the B1 calibration of the two RF coil types used were observed.Our results show that quantitative brain imaging can be performed with high reproducibility at 7 T and with similar reliability as found at 3 T for multicenter studies of the supratentorial brain.

Keyword(s): Magnetic resonance imaging ; multicenter ; quantitative imaging ; reproducibility ; ultrahigh field

Note: 2021 May 15;232:117910

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Contributing Institute(s):

1. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2021

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