Journal Article

DKFZ-2021-00622

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Three-dimensionally two-photon lithography realized vascular grafts.

Limongi, T. ; Brigo, L. ; Tirinato, L.DKFZ* ; Pagliari, F.DKFZ* ; Gandin, A. ; Contessotto, P. ; Giugni, A. ; Brusatin, G.

2021
Inst. of Physics London

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Please use a persistent id in citations: doi:10.1088/1748-605X/abca4b

Abstract: Generation of artifical vascular grafts (TEVG) as blood vessel substitutes is a primary challenge in biomaterial and tissue engineering research. Ideally, these grafts should be able to recapitulate physiological and mechanical properties of natural vessels and guide the assembly of an endothelial cell lining to ensure hemo-compatibility. In this paper, we advance on this challenging task by designing and fabricating 3D vessel analogues by two-photon laser lithography using a synthetic photoresist. These scaffolds guarantee human endothelial cell adhesion and proliferation, and proper elastic behaviour to withstand the pressure exerted by blood flow.

Keyword(s): 3D Fabrication ; Microstructured scaffolds ; Two-photon laser lithography ; endothelial cells ; vascular tissue engineering

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Contributing Institute(s):

1. E041 Medizinische Physik in der Radioonkologie (E041)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2021

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Database coverage:
; Clarivate Analytics Master Journal List ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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