Journal Article

DKFZ-2021-01098

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort study.

Mayén, A.-L. ; Aglago, E. K. ; Knaze, V. ; Cordova, R. ; Schalkwijk, C. G. ; Wagner, K.-H. ; Aleksandrova, K. ; Fedirko, V. ; Keski-Rahkonen, P. ; Leitzmann, M. F. ; Katzke, V.DKFZ* ; Srour, B.DKFZ* ; Schulze, M. B. ; Masala, G. ; Krogh, V. ; Panico, S. ; Tumino, R. ; Bueno-de-Mesquita, B. ; Brustad, M. ; Agudo, A. ; Chirlaque López, M. D. ; Amiano, P. ; Ohlsson, B. ; Ramne, S. ; Aune, D. ; Weiderpass, E. ; Jenab, M. ; Freisling, H.

2021
Wiley-Liss Bognor Regis

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Please use a persistent id in citations: doi:10.1002/ijc.33612

Abstract: Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their proinflammatory and prooxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer etiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n = 450 111). Dietary intake of three AGEs, Nε -[carboxymethyl]lysine (CML), Nε -[1-carboxyethyl]lysine (CEL) and Nδ -[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), was estimated using country-specific dietary questionnaires linked to an AGEs database. Cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations between dietary AGEs and risk of hepatocellular carcinoma (HCC), gallbladder and biliary tract cancers were estimated using multivariable Cox proportional hazard regression. After a median follow-up time of 14.9 years, 255 cases of HCC, 100 cases of gallbladder cancer and 173 biliary tract cancers were ascertained. Higher intakes of dietary AGEs were inversely associated with the risk of HCC (per 1 SD increment, HR-CML  = 0.87, 95% CI: 0.76-0.99, HR-CEL  = 0.84, 95% CI: 0.74-0.96 and HR-MH-G1  = 0.84, 95% CI: 0.74-0.97). In contrast, positive associations were observed with risk of gallbladder cancer (per 1 SD, HR-CML  = 1.28, 95% CI: 1.05-1.56, HR-CEL  = 1.17; 95% CI: 0.96-1.40, HR-MH-G1  = 1.27, 95% CI: 1.06-1.54). No associations were observed for cancers of the intra and extrahepatic bile ducts. Our findings suggest that higher intakes of dietary AGEs are inversely associated with the risk of HCC and positively associated with the risk of gallbladder cancer.

Keyword(s): EPIC study ; advanced glycation endproducts ; bile duct cancers ; gallbladder cancer ; hepatocellular carcinoma

Note: 2021 Apr 25;149(4):854-864

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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