Journal Article (Review Article)

DKFZ-2021-01885

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Deep learning-based synthetic-CT generation in radiotherapy and PET: a review.

Spadea, M. F. ; Maspero, M. ; Zaffino, P. ; Seco, J. (Last author)DKFZ*

2021
AAPM College Park, Md.

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Please use a persistent id in citations: doi:10.1002/mp.15150

Abstract: Recently, deep learning (DL)-based methods for the generation of synthetic computed tomography (sCT) have received significant research attention as an alternative to classical ones. We present here a systematic review of these methods by grouping them into three categories, according to their clinical applications: I) to replace CT in magnetic resonance (MR)-based treatment planning, II) facilitate cone-beam computed tomography (CBCT)-based image-guided adaptive radiotherapy, and III) derive attenuation maps for the correction of positron emission tomography (PET). Appropriate database searching was performed on journal articles published between January 2014 and December 2020. The DL methods' key characteristics were extracted from each eligible study, and a comprehensive comparison among network architectures and metrics was reported. A detailed review of each category was given, highlighting essential contributions, identifying specific challenges, and summarising the achievements. Lastly, the statistics of all the cited works from various aspects were analysed, revealing the popularity and future trends and the potential of DL-based sCT generation. The current status of DL-based sCT generation was evaluated, assessing the clinical readiness of the presented methods.

Note: #LA:E041# / 2021 Nov;48(11):6537-6566

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Contributing Institute(s):

1. E041 Medizinische Physik in der Radioonkologie (E041)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2021

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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