Journal Article (Review Article)

DKFZ-2021-02508

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Bovine Meat and Milk Factors (BMMFs): Their Proposed Role in Common Human Cancers and Type 2 Diabetes Mellitus.

de Villiers, E.-M. (First author)DKFZ* ; zur Hausen, H. (Last author)DKFZ*

2021
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/cancers13215407

Abstract: Exemplified by infections with bovine meat and milk factors (BMMFs), this manuscript emphasizes the different mechanistic aspects of infectious agents contributing to human cancers by 'direct' or 'indirect' interactions. The epidemiology of cancers linked to direct carcinogens (e.g., response to immunosuppression) differs from those cancers linked with indirect infectious interactions. Cancers induced by direct infectious carcinogens commonly increase under immunosuppression, whereas the cancer risk by indirect carcinogens is reduced. This influences their responses to preventive and therapeutic interferences. In addition, we discuss their role in colon, breast and prostate cancers and type II diabetes mellitus. A brief discussion covers the potential role of BMMF infections in acute myeloid leukemia.

Keyword(s): bovine meat and milk factors (BMMF) ; chronic zoonosis ; indirect carcinogenesis

Note: #EA:F200#LA:F200#

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Contributing Institute(s):

1. F200 Arbeitsgruppe Episomal-Persistierende DNA in Krebs- und chron. Erkrankungen (F200)

Research Program(s):

1. 316 - Infektionen, Entzündung und Krebs (POF4-316) (POF4-316)

Appears in the scientific report 2021

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