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| Home > Publications database > Definition and Characterization of SOX11-Derived T Cell Epitopes towards Immunotherapy of Glioma. |
| Home > Publications database > Definition and Characterization of SOX11-Derived T Cell Epitopes towards Immunotherapy of Glioma. |
| Journal Article | DKFZ-2023-00333 |
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2023
Molecular Diversity Preservation International
Basel
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Please use a persistent id in citations: doi:10.3390/ijms24031943
Abstract: The transcription factor SOX11 is a tumor-associated antigen with low expression in normal cells, but overexpression in glioblastoma (GBM). So far, conventional surgery, chemotherapy, and radiotherapy have not substantially improved the dismal prognosis of relapsed/refractory GBM patients. Immunotherapy is considered a promising strategy against GBM, but there is a fervent need for better immunotargets in GBM. To this end, we performed an in silico prediction study on SOX11, which primarily yielded ten promising HLA-A*0201-restricted peptides derived from SOX11. We defined a novel peptide FMACSPVAL, which had the highest score according to in silico prediction (6.02 nM by NetMHC-4.0) and showed an exquisite binding affinity to the HLA-A*0201 molecule in the peptide-binding assays. In the IFN-γ ELISPOT assays, FMACSPVAL demonstrated a high efficiency for generating SOX11-specific CD8+ T cells. Nine out of thirty-two healthy donors showed a positive response to SOX11, as assessed by the ELISPOT assays. Therefore, this novel antigen peptide epitope seems to be promising as a target for T cell-based immunotherapy in GBM. The adoptive transfer of in vitro elicited SOX11-specific CD8+ T cells constitutes a potential approach for the treatment of GBM patients.
Keyword(s): HLA-A*0201 ; SOX11 ; glioma ; immunotherapy ; tumor-associated antigen
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