Journal Article (Review Article)

DKFZ-2023-00954

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The PANcreatic Disease ReseArch (PANDoRA) consortium: ten years' experience of association studies to understand the genetic architecture of pancreatic cancer.

Campa, D. ; Gentiluomo, M. ; Stein, A.DKFZ* ; Aoki, M. N. ; Oliverius, M. ; Vodičková, L. ; Jamroziak, K. ; Theodoropoulos, G. ; Pasquali, C. ; Greenhalf, W. ; Arcidiacono, P. G. ; Uzunoglu, F. ; Pezzilli, R. ; Luchini, C. ; Puzzono, M. ; Loos, M. ; Giaccherini, M. ; Katzke, V.DKFZ* ; Mambrini, A. ; Kiudeliene, E. ; Federico, K. E. ; Johansen, J. ; Hussein, T. ; Mohelnikova-Duchonova, B. ; van Eijck, C. H. J. ; Brenner, H.DKFZ* ; Farinella, R. ; Pérez, J. S. ; Lovecek, M. ; Büchler, M. W. ; Hlavac, V. ; Izbicki, J. R. ; Hackert, T. ; Chammas, R. ; Zerbi, A. ; Lawlor, R. ; Felici, A. ; Götz, M. ; Capurso, G. ; Ginocchi, L. ; Gazouli, M. ; Kupcinskas, J. ; Cavestro, G. M. ; Vodicka, P. ; Moz, S. ; Neoptolemos, J. P. ; Kunovsky, L. ; Bojesen, S. E. ; Carrara, S. ; Gioffreda, D. ; Morkunas, E. ; Abian, O. ; Bunduc, S. ; Basso, D. ; Boggi, U. ; Wlodarczyk, B. ; Szentesi, A. ; Vanella, G. ; Chen, I. ; Bijlsma, M. F. ; Kiudelis, V. ; Landi, S. ; Schöttker, B.DKFZ* ; Corradi, C. ; Giese, N. ; Kaaks, R.DKFZ* ; Peduzzi, G. ; Hegyi, P. ; Morelli, L. ; Furbetta, N. ; Soucek, P. ; Latiano, A. ; Talar-Wojnarowska, R. ; Lindgaard, S. C. ; Dijk, F. ; Milanetto, A. C. ; Tavano, F. ; Cervena, K. ; Erőss, B. ; Testoni, S. G. ; Verhagen-Oldenampsen, J. H. E. ; Małecka-Wojciesko, E. ; Costello, E. ; Salvia, R. ; Maiello, E. ; Ermini, S. ; Sperti, C. ; Holleczek, B.DKFZ* ; Perri, F. ; Skieceviciene, J. ; Archibugi, L. ; Lucchesi, M. ; Rizzato, C. ; Canzian, F. (Last author)DKFZ*

2023
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.critrevonc.2023.104020

Abstract: Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.

Keyword(s): Pancreatic cancer ; chronic pancreatitis ; consortium ; genetic epidemiology ; intraductal papillary mucinous neoplasms ; pancreatic ductal adenocarcinoma ; pancreatic neuroendocrine tumors

Note: #LA:C055#

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Contributing Institute(s):

1. C055 Genomische Epidemiologie (C055)
2. C020 Epidemiologie von Krebs (C020)
3. C070 Klinische Epidemiologie und Alternf. (C070)
4. Präventive Onkologie (C120)
5. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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