Journal Article (Review Article)

DKFZ-2023-00969

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png ARID1A mutations in lung cancer: biology, prognostic role, and therapeutic implications.

Jin, F. (First author)DKFZ* ; Yang, Z. ; Shao, J. ; Tao, J.DKFZ* ; Reißfelder, C. ; Loges, S.DKFZ* ; Zhu, L.DKFZ* ; Schölch, S. (Last author)DKFZ*

2023
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.molmed.2023.04.005

Abstract: Mutations in the AT-interacting domain-rich protein 1A (ARID1A) gene, a critical component of the switch/sucrose nonfermentable (SWI/SNF) complex, are frequently found in most human cancers. Approximately 5-10% of lung cancers carry ARID1A mutations. ARID1A loss in lung cancer correlates with clinicopathological features and poor prognosis. Co-mutation of ARID1A and epidermal growth factor receptor (EGFR) results in the limited efficacy of EGFR tyrosine kinase inhibitors (EGFR-TKIs) but increases the clinical benefit of immune checkpoint inhibitors (ICIs). ARID1A gene mutation plays a role in cell cycle regulation, metabolic reprogramming, and epithelial-mesenchymal transition. We present the first comprehensive review of the relationship between ARID1A gene mutations and lung cancer and discuss the potential of ARID1A as a new molecular target.

Keyword(s): ARID1A ; SWI/SNF complex ; cell cycle regulation ; epithelial–mesenchymal transition ; lung cancer ; metabolic reprogramming

Note: #EA:A430#LA:A430# / 2023 Aug;29(8):646-658

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Contributing Institute(s):

1. NWG-KKE Translationale Chirurgische Onkologie (A430)
2. Personalisierte Medizinische Onkologie (A420)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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