Journal Article

DKFZ-2023-01003

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sexually transmitted infections and risk of epithelial ovarian cancer: results from the Finnish Maternity Cohort.

Skarga, E. (First author)DKFZ* ; Surcel, H.-M. ; Kaaks, R.DKFZ* ; Waterboer, T.DKFZ* ; Turzanski-Fortner, R. (Last author)DKFZ*

2023
Oxford Univ. Press Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1093/infdis/jiad171

Abstract: Sexually transmitted infections, specifically Chlamydia trachomatis (CT), may be associated with epithelial ovarian cancer (EOC) risk. The association between CT and EOC subtypes is unclear. Our aim was to investigate whether history of CT and other infections (M. genitalium (MG), herpes simplex virus type 2, and human papillomaviruses) are associated with EOC risk by histotype.We measured antibodies (Ab) to CT, MG, HSV2, and HPV-16 and 18 in serum samples in a nested case-control study in the Finnish Maternity Cohort (n= 484 cases 1:1 matched to controls). Logistic Regression was used to calculate relative risks (RRs) and 95% confidence intervals [CIs] in seropositive vs. seronegative individuals in all cases, as well as serous (n=249), clear cell and endometrioid (n=91), and mucinous (n=142) EOC.CT-seropositivity was not associated with EOC risk (e.g., CT pGP3-Ab RR=0.92 [0.72- 1.19]), regardless of disease subtype. We observed a positive association between MG-seropositivity and mucinous EOC (RR=1.66 [1.09-2.54]; p-het_histotype≤0.001), but not other subtypes. No associations were observed with seropositivity to multiple STIs.CT infection was not associated with EOC risk, with associations observed only for MG and mucinous EOC. Mechanisms linking MG to mucinous EOC remain to be elucidated.

Keyword(s): Chlamydia Trachomatis ; Ovarian Cancer ; Risk ; Serology ; Sexually Transmitted Infections

Note: #EA:C020#LA:C020# / 2023 Nov 28;228(11):1621-1629

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. Infektionen und Krebs-Epidemiologie (F020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; National-Konsortium ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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