Journal Article

DKFZ-2023-01206

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC).

Ersoy Guller, Z. ; Harewood, R. N. ; Weiderpass, E. ; Huybrechts, I. ; Jenab, M. ; Huerta, J. M. ; Sánchez, M.-J. ; Jakszyn, P. ; Amiano, P. ; Ardanaz, E. ; Agnoli, C. ; Tumino, R. ; Palli, D. ; Skeie, G. ; Manjer, J. ; Papier, K. ; Tjønneland, A. ; Eriksen, A. K. ; Schulze, M. B. ; Kaaks, R.DKFZ* ; Katzke, V.DKFZ* ; Bergmann, M. M. ; Riboli, E. ; Gunter, M. J. ; Cross, A. J.

2023
Springer Science + Business Media B.V. Dordrecht [u.a.]

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Please use a persistent id in citations: doi:10.1007/s10552-023-01731-w

Abstract: The incidence of small intestinal cancer (SIC) is increasing, however, its aetiology remains unclear due to a lack of data from large-scale prospective cohorts. We examined modifiable risk factors in relation to SIC overall and by histological subtype.We analysed 450,107 participants enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. Cox proportional hazards models were used to estimate univariable and multivariable hazard ratios (HRs) and 95% confidence intervals (CIs).During an average of 14.1 years of follow-up, 160 incident SICs (62 carcinoids, 51 adenocarcinomas) were identified. Whilst univariable models revealed a positive association for current versus never smokers and SIC (HR, 95% CI: 1.77, 1.21-2.60), this association attenuated in multivariable models. In energy-adjusted models, there was an inverse association across vegetable intake tertiles for SIC overall (HRT3vsT1, 95% CI: 0.48, 0.32-0.71, p-trend: < 0.001) and for carcinoids (HRT3vsT1, 95% CI: 0.44, 0.24-0.82, p-trend: 0.01); however, these attenuated in multivariable models. Total fat was also inversely associated with total SIC and both subtypes but only in the second tertile (SIC univariable HRT2vsT1, 95% CI: 0.57, 0.38-0.84; SIC multivariable HRT2vsT1, 95% CI: 0.55, 0.37-0.81). Physical activity, intake of alcohol, red or processed meat, dairy products, or fibre were not associated with SIC.These exploratory analyses found limited evidence for a role of modifiable risk factors in SIC aetiology. However, sample size was limited, particularly for histologic subtypes; therefore, larger studies are needed to delineate these associations and robustly identify risk factors for SIC.

Keyword(s): Adenocarcinoma ; Alcohol ; Cancer ; Carcinoid ; Diet ; Lifestyle ; Small intestine ; Smoking

Note: 2023 Oct;34(10):927-937

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; DEAL Springer ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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