Journal Article

DKFZ-2023-01361

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke.

Ebersberger, L. (First author)DKFZ* ; Kratzer, F. J.DKFZ* ; Potreck, A. ; Niesporek, S.DKFZ* ; Keymling, M.DKFZ* ; Nagel, A. M.DKFZ* ; Bendszus, M. ; Wick, W. ; Ladd, M. E.DKFZ* ; Schlemmer, H.-P.DKFZ* ; Hoffmann, A. ; Platt, T. (Last author)DKFZ* ; Paech, D. (Last author)DKFZ*

2023
Frontiers Research Foundation Lausanne

Abstract: Dynamic oxygen-17 (17O) magnetic resonance imaging (MRI) is an imaging method that enables a direct and non-invasive assessment of cerebral oxygen metabolism and thus potentially the distinction between viable and non-viable tissue employing a three-phase inhalation experiment. The purpose of this investigation was the first application of dynamic 17O MRI at 7 Tesla (T) in a patient with stroke. In this proof-of-concept experiment, dynamic 17O MRI was applied during 17O inhalation in a patient with early subacute stroke. The analysis of the relative 17O water (H217O) signal for the affected stroke region compared to the healthy contralateral side revealed no significant difference. However, the technical feasibility of 17O MRI has been demonstrated paving the way for future investigations in neurovascular diseases.

Keyword(s): 7 Tesla ; metabolic imaging ; oxygen metabolism ; oxygen-17 MRI ; stroke ; ultra-high field

Note: #EA:E010#LA:E010#LA:E020#

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Contributing Institute(s):

1. E010 Radiologie (E010)
2. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2023

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