Journal Article

DKFZ-2023-02218

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage.

Ho, K. H. (First author)DKFZ* ; Candat, A. ; Scarpetta, V.DKFZ* ; Faucourt, M. ; Weill, S. ; Salio, C. ; D'Este, E. ; Meschkat, M. ; Wurm, C. A. ; Kneussel, M. ; Janke, C. ; Magiera, M. M. ; Genovesio, A. ; Meunier, A. ; Sassoè-Pognetto, M. ; Brill, M. S. ; Spassky, N. ; Patrizi, A. (Last author)DKFZ*

2023
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.devcel.2023.10.003

Abstract: Choroid plexuses (ChPs) produce cerebrospinal fluid and sense non-cell-autonomous stimuli to control the homeostasis of the central nervous system. They are mainly composed of epithelial multiciliated cells, whose development and function are still controversial. We have thus characterized the stepwise order of mammalian ChP epithelia cilia formation using a combination of super-resolution-microscopy approaches and mouse genetics. We show that ChP ciliated cells are built embryonically on a treadmill of spatiotemporally regulated events, starting with atypical centriole amplification and ending with the construction of nodal-like 9+0 cilia, characterized by both primary and motile features. ChP cilia undergo axoneme resorption at early postnatal stages through a microtubule destabilization process controlled by the microtubule-severing enzyme spastin and mitigated by polyglutamylation levels. Notably, this phenotype is preserved in humans, suggesting a conserved ciliary resorption mechanism in mammals.

Keyword(s): aging ; basal feet ; cilia ; development ; electron microscopy ; embryogenesis ; human choroid plexus ; multiciliogenesis ; polyglutamylation ; quantitative imaging

Note: DKFZ-ZMBH Alliance / #EA:A320#LA:A320# / 2023 Dec 4;58(23):2641-2651.e6

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Contributing Institute(s):

1. A320 NWG Neuronal signaling and morphogenesis (A320)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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