Journal Article (Review Article)

DKFZ-2024-00856

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Spatially fractionated radiation therapy: a critical review on current status of clinical and preclinical studies and knowledge gaps.

Prezado, Y. ; Grams, M. ; Jouglar, E. ; Martinez-Rovira, I. ; Ortiz, R. ; Seco, J.DKFZ* ; Chang, S.

2024
IOP Publ. Bristol

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Please use a persistent id in citations: doi:10.1088/1361-6560/ad4192

Abstract: Spatially fractionated radiation therapy (SFRT) is a therapeutic approach with the potential to disrupt the classical paradigms of conventional radiation therapy. The high spatial dose modulation in SFRT activates distinct radiobiological mechanisms which lead to a remarkable increase in normal tissue tolerances. Several decades of clinical use and numerous preclinical experiments suggest that SFRT has the potential to increase the therapeutic index, especially in bulky and radioresistant tumors. To unleash the full potential of SFRT a deeper understanding of the underlying biology and its relationship with the complex dosimetry of SFRT is needed. This review provides a critical analysis of the field, discussing not only the main clinical and preclinical findings but also analyzing the main knowledge gaps in a holistic way.

Keyword(s): Spatially fractionated radiotherapy ; normal tissue tolerances ; uncoventional radiotherapy

Note: Phys. Med. Biol. 69 (2024) 10TR02

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Contributing Institute(s):

1. Med. Physik in der Radioonkologie (E041)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2024

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Database coverage:
; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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