guest ::
| Home > Publications database > An 'R-spondin code' for multimodal signaling ON-OFF states. |
| Home > Publications database > An 'R-spondin code' for multimodal signaling ON-OFF states. |
| Journal Article (Review Article) | DKFZ-2024-01723 |
; ;
2024
Wiley-Liss
New York, NY
This record in other databases: 
Please use a persistent id in citations: doi:10.1002/bies.202400144
Abstract: R-spondins (RSPOs) are a family of secreted proteins and stem cell growth factors that are potent co-activators of Wnt signaling. Recently, RSPO2 and RSPO3 were shown to be multifunctional, not only amplifying Wnt- but also binding BMP- and FGF receptors to downregulate signaling. The common mechanism underlying these diverse functions is that RSPO2 and RSPO3 act as 'endocytosers' that link transmembrane proteins to ZNRF3/RNF43 E3 ligases and trigger target internalization. Thus, RSPOs are natural protein targeting chimeras for cell surface proteins. Conducting data mining and cell surface binding assays we report additional candidate RSPO targets, including SMO, PTC1,2, LGI1, ROBO4, and PTPR(F/S). We propose that there is an 'R-spondin code' that imparts combinatorial signaling ON-OFF states of multiple growth factors. This code involves the modular RSPO domains, notably distinct motifs in the divergent RSPO-TSP1 domains to mediate target interaction and internalization. The RSPO code offers a novel framework for the understanding how diverse signaling pathways may be coordinately regulated in development and disease.
Keyword(s): BMP ; FGF ; Hedgehog ; R‐spondin ; Wnt ; axon guidance ; phosphatases ; receptor internalization
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz
; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record
|
The record appears in these collections: |
PDF
PDF (PDFA)