Journal Article (Review Article)

DKFZ-2024-01771

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The oncological role of resection in newly diagnosed diffuse adult-type glioma defined by the WHO 2021 classification: a Review by the RANO resect group.

Karschnia, P.DKFZ* ; Gerritsen, J. K. W. ; Teske, N.DKFZ* ; Cahill, D. P. ; Jakola, A. S. ; van den Bent, M. ; Weller, M. ; Schnell, O. ; Vik-Mo, E. O. ; Thon, N.DKFZ* ; Vincent, A. J. P. E. ; Kim, M. M. ; Reifenberger, G.DKFZ* ; Chang, S. M. ; Hervey-Jumper, S. L. ; Berger, M. S. ; Tonn, J.-C.DKFZ*

2024
The Lancet Publ. Group London

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Please use a persistent id in citations: doi:10.1016/S1470-2045(24)00130-X

Abstract: Glioma resection is associated with prolonged survival, but neuro-oncological trials have frequently refrained from quantifying the extent of resection. The Response Assessment in Neuro-Oncology (RANO) resect group is an international, multidisciplinary group that aims to standardise research practice by delineating the oncological role of surgery in diffuse adult-type gliomas as defined per WHO 2021 classification. Favourable survival effects of more extensive resection unfold over months to decades depending on the molecular tumour profile. In tumours with a more aggressive natural history, supramaximal resection might correlate with additional survival benefit. Weighing the expected survival benefits of resection as dictated by molecular tumour profiles against clinical factors, including the introduction of neurological deficits, we propose an algorithm to estimate the oncological effects of surgery for newly diagnosed gliomas. The algorithm serves to select patients who might benefit most from extensive resection and to emphasise the relevance of quantifying the extent of resection in clinical trials.

Keyword(s): Humans (MeSH) ; Glioma: surgery (MeSH) ; Glioma: pathology (MeSH) ; Glioma: classification (MeSH) ; Glioma: mortality (MeSH) ; Brain Neoplasms: surgery (MeSH) ; Brain Neoplasms: pathology (MeSH) ; Brain Neoplasms: classification (MeSH) ; Brain Neoplasms: mortality (MeSH) ; World Health Organization (MeSH) ; Algorithms (MeSH) ; Adult (MeSH) ; Neurosurgical Procedures: adverse effects (MeSH) ; Treatment Outcome (MeSH)

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Contributing Institute(s):

1. DKTK Koordinierungsstelle München (MU01)
2. DKTK Koordinierungsstelle Essen/Düsseldorf (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2024

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 50 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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