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| Home > Publications database > Portal and Hepatic Vein Embolization vs Portal Venous Embolization Alone in Cirrhotic and Non-cirrhotic Swine: A Pilot Study. |
| Home > Publications database > Portal and Hepatic Vein Embolization vs Portal Venous Embolization Alone in Cirrhotic and Non-cirrhotic Swine: A Pilot Study. |
| Journal Article | DKFZ-2025-00490 |
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2025
Elsevier
Amsterdam [u.a.]
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Please use a persistent id in citations: doi:10.1016/j.jvir.2025.02.028
Abstract: To evaluate the effectiveness of PVE and HVE compared to PVE in cirrhotic and non-cirrhotic swine.Sixteen Yorkshire pigs were included in this study. In the cirrhotic group (n = 8) and non-cirrhotic group (n = 8), subjects underwent embolization according to established protocols. CT scans were acquired before and at two- and four-week intervals following the embolization. Liver volumes were segmented in the portal venous phase. Student's t-test with a significance level at p<0.05 was used.Across all swine, the FLR was significantly larger after PVE + HVE to PVE at two weeks (24.12% [95% CI: 15.36%, 32.88%] vs. 12.75% [95% CI: 7.43%, 18.07%], p = 0.021) and four weeks (23.23% [95% CI: 15.79%, 33.47%] vs. 15.08% [95% CI: 9.98%, 20.87%], p = 0.043) post-embolization. In the cirrhotic group, the FLR increase was greater following PVE + HVE compared to PVE at two weeks (20.85% [95% CI: 14.40%, 27.30%] vs. 8.66% [95% CI: 6.47%, 10.86%], p = 0.0089) and four weeks (19.27% [95% CI: 17.87%, 20.67%] vs. 13.33% [95% CI: 9.23%, 13.33%], p = 0.0003) post-embolization.PVE + HVE resulted in greater FLR hypertrophy than PVE alone indicating that cirrhotic livers may benefit from the addition of HVE.
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