Journal Article (Review Article)

DKFZ-2025-00856

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Choroid plexus: Insights from distinct epithelial cellular components.

Scarpetta, V. (First author)DKFZ* ; Ho, K. H.DKFZ* ; Trapp, M.DKFZ* ; Patrizi, A. (Last author)DKFZ*

2025
Current Biology Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1016/j.conb.2025.103028

Abstract: The choroid plexus (ChP) serves as a vital interface between blood and cerebrospinal fluid (CSF), playing a pivotal role in central nervous system (CNS) development and communication with the body. This review mainly summarizes how the ChP epithelial cells respond to physiological and pathological stimuli, emphasizing the role of distinct organelles and key molecular signaling pathways. Additionally, we discuss the roles of ChP cilia, an evolutionary conserved organelle whose function is still under investigation. Understanding these processes is essential for elucidating how ChP function modulates intrinsic and extrinsic stimuli, which are crucial for maintaining CNS and body homeostasis.

Note: #EA:A320#LA:A320# / Schaller Research Group, German Cancer Research Center (DKFZ)

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Contributing Institute(s):

1. A320 NWG Neuronal signaling and morphogenesis (A320)
2. A010 Stammzellen und Krebs (A010)
3. Translationale Pädiatrische Sarkomforschung (B410)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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