Journal Article

DKFZ-2025-00940

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Spatial-Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment.

Lv, W. ; Zeng, Y. ; Li, C. ; Liang, Y. ; Tao, H. ; Zhu, Y. ; Sui, X. ; Li, Y. ; Jiang, S. ; Gao, Q. ; Rodriguez-Fos, E. ; Prasad, G. ; Wang, Y. ; Zhou, R. ; Xu, Z. ; Pan, X. ; Chen, L. ; Xiang, X. ; Teng, H. ; Sun, C. ; Qin, T. ; Dong, W. ; Li, Y. ; Lan, X. ; Li, X. ; Lin, L. ; Bolund, L. ; Yang, H. ; Verhaak, R. G. W. ; Faltas, B. M. ; Hansen, J. B. ; Wu, S. ; Mischel, P. S. ; Henssen, A. G.DKFZ* ; Bafna, V. ; Luebeck, J. ; Regenberg, B. ; Luo, Y. ; Lin, C. ; Han, P.

2025
[Verlag nicht ermittelbar] Philadelphia, Pa.

This record in other databases:  

Please use a persistent id in citations: doi:10.1158/2159-8290.CD-24-1532

Abstract: Our comprehensive analysis of ecDNA in urothelial carcinoma reveals its crucial role in driving the evolution and heterogeneity of multifocal cancer, as well as its early involvement in tumorigenesis. Moreover, this study sheds light on immune evasion mechanisms associated with ecDNA and offers valuable insights for developing targeted therapeutic strategies.

Note: Cancer Discov (2025) 15 (6): 1225–1246

---

Contributing Institute(s):

1. DKTK Koordinierungsstelle Berlin (BE01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Essential Science Indicators ; IF >= 25 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---