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Metachronous colorectal cancer risks after extended or segmental resection in MLH1 , MSH2 , and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database
Zalevskaja, K. ; Ojala, K. ; Petrov, A. ; Haupt, S. ; Sunde, L. ; Bernstein, I. ; Jenkins, M. A. ; Aretz, S. ; Nielsen, M. ; Capella, G. ; Balaguer, F. ; Evans, D. G. ; Burn, J. ; Holinski-Feder, E. ; Bertario, L. ; Bonanni, B. ; Lindblom, A. ; Levi, Z. ; Macrae, F. ; Winship, I. ; Plazzer, J.-P. ; Sijmons, R. ; Laghi, L. ; Della Valle, A. ; Heinimann, K. ; Dębniak, T. ; Fruscio, R. ; Lopez-Koestner, F. ; Alvarez-Valenzuela, K. ; Katz, L. H. ; Laish, I. ; Vainer, E. ; Vaccaro, C. ; Carraro, D. M. ; Monahan, K. ; Half, E. ; Stakelum, A. ; Winter, D. ; Kennelly, R. ; Gluck, N. ; Sheth, H. ; Abu-Freha, N. ; Greenblatt, M. ; Rossi, B. M. ; Bohorquez, M. ; Cavestro, G. M. ; Lino-Silva, L. S. ; Horisberger, K. ; Tibiletti, M. G. ; do Nascimento, I. ; Thomas, H. ; Rossi, N. T. ; da Silva, L. A. ; Zaránd, A. ; Ruiz-Bañobre, J. ; Heuveline, V. ; Lindberg, L. J. ; Gögenur, I. ; Hopper, J. L. ; Win, A. K. ; Haile, R. W. ; Lindor, N. ; Gallinger, S. ; Le Marchand, L. ; Newcomb, P. A. ; Figueiredo, J. ; Buchanan, D. D. ; Thibodeau, S. N. ; von Knebel Doeberitz, M.DKFZ* ; Loeffler, M. ; Rahner, N. ; Schröck, E.DKFZ* ; Steinke-Lange, V. ; Schmiegel, W. ; Vangala, D. ; Perne, C. ; Hüneburg, R. ; Redler, S.DKFZ* ; Büttner, R. ; Weitz, J. ; Pineda, M. ; Duenas, N. ; Brunet Vidal, J. ; Moreira, L. ; Sánchez, A. ; Castillo-Iturra, J. ; Hovig, E. ; Green, K. ; Lalloo, F. ; Hill, J. ; Crosbie, E. ; Mints, M. ; Goldberg, Y. ; Tjandra, D. ; ten Broeke, S. W. ; Kariv, R. ; Rosner, G. ; Jain, A. ; Shah, P. ; Shah, M. ; Neffa, F. ; Esperon, P. ; Pavicic, W. ; Torrezan, G. T. ; Bassaneze, T. ; Martin, C. A. ; Pylvänäinen, K. ; Möslein, G. ; Lepistö, A. ; Mecklin, J.-P. ; Renkonen-Sinisalo, L. ; Sampson, J. R. ; Dominguez Valentin, M. ; Møller, P. ; Seppälä, T. T.
2025
Oxford University Press
Oxford
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Please use a persistent id in citations: doi:10.1093/bjs/znaf061
Abstract: This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.
Contributing Institute(s):
- KKE Angewandte Tumorbiologie (D470)
- DKTK Koordinierungsstelle Dresden (DD01)
Research Program(s):
- 314 - Immunologie und Krebs (POF4-314) (POF4-314)
Appears in the scientific report
2025
Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz

; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection