Journal Article (Review Article)

DKFZ-2025-01032

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Innovative Therapeutic Strategies Targeting the Network Architecture of Glioblastoma.

Beichert, J. ; Hoffmann, D. C. F.DKFZ* ; Winkler, F.DKFZ* ; Ratliff, M. (Last author)DKFZ*

2025
AACR Philadelphia, Pa. [u.a.]

Abstract: Recent discoveries concerning the network architecture of glioblastoma, including tumor microtubules (TMs) and neuron-glioma synapses, have underscored critical pathways that sustain tumor growth, enhance resistance, and integrate glioblastoma with the surrounding neural environment. This review explores emerging therapeutic strategies targeting these pathways, including inhibitors of gap junctions, AMPA receptors, and glutamate signaling, which are currently being tested in clinical trials. By consolidating these advances, this review seeks to bridge the gap between neurobiology, cancer neuroscience, and oncology, proposing novel approaches to overcome resistance and improve patient outcomes. The insights derived from this comprehensive review hold the potential to significantly influence the future management of glioblastoma.

Note: #LA:B320# / 2025 Jul 15;31(14):2864-2871

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Contributing Institute(s):

1. KKE Neuroonkologie (B320)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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