Journal Article

DKFZ-2025-01969

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Remote control of AMPK via extracellular adenosine controls tissue growth.

Zhang, Y. (First author)DKFZ* ; Strassburger, K.DKFZ* ; Teleman, A. (Last author)DKFZ*

2025
Nature America New York, NY

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Please use a persistent id in citations: doi:10.1038/s41556-025-01764-0

Abstract: Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a regulator of cellular catabolism that is activated by AMP. As AMP accumulates in cells with low ATP, AMPK is considered a stress-activated kinase. While studying organ growth during Drosophila development, we find that AMPK can also be activated by a signalling metabolite not related to stress. Specifically, we find that two physiological inputs known to regulate organ growth rates (ecdysone (a steroid hormone) and dietary protein) modulate expression of adenosine deaminase in the intestine. This, in turn, alters circulating adenosine levels. Circulating adenosine acts as a signalling molecule by entering cells, becoming phosphorylated to AMP and activating AMPK to inhibit organ growth. Thus, AMPK activity is regulated developmentally, and AMPK activity in one tissue can be remote controlled by another tissue via circulating adenosine. Notably, this mechanism accounts for half the effect of dietary protein on tissue growth rates in Drosophila.

Note: #EA:B140#LA:B140# / 2025 Oct;27(10):1827-1837

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Contributing Institute(s):

1. B140 Signal Transduction in Cancer (B140)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2025

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