Journal Article

DKFZ-2025-02423

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Longitudinal Associations of Sedentary Behavior and Physical Activity With Sleep Duration and Quality in Individuals Living With and Beyond Colorectal Cancer.

Frenken, K. G. ; Buffart, L. M. ; Bours, M. ; Breukink, S. O. ; Janssen-Heijnen, M. ; Konsten, J. ; Keulen, E. T. P. ; Siffels, A. ; Koster, A. ; Meijer, K. ; Scheer, F. A. J. L. ; Steindorf, K.DKFZ* ; Geelen, J. d. V. ; Weijenberg, M. P. ; Roekel, E. H. v.

2025
Sage Publications Thousand Oaks, CA

Abstract: IntroductionPoor sleep quality and disturbances are common in colorectal cancer (CRC) survivors. However, the impact of sedentary behavior, standing, and physical activity on sleep duration and quality remains under-explored in this population. Therefore, this study examined longitudinal associations of sedentary behavior, standing, and physical activity with sleep outcomes up to 5 years post-treatment.MethodsA prospective cohort study was conducted among 401 survivors of stage I-III CRC, with repeated measures up to 60 months post-treatment. Thigh-worn accelerometers were used to measure sedentary time (per 2h/day), standing (per 1h/day), and various levels of physical activity (per 1h/day). Sleep duration (h/night) and variability (0%-100%; higher variability equals more sleep disruption) were determined from self-reported sleep times. Sleep quality and insomnia symptoms were assessed using the PSQI and EORTC questionnaires, respectively, where higher scores indicated worsened symptoms. Longitudinal associations were analyzed using confounder-adjusted linear mixed models.ResultsTotal mean sedentary time was 10.3 ± 1.8 h/day, mean standing time was 2.9 ± 1.2 h/day, mean total physical activity was 1.5 ± 0.6 h/day, and mean sleep duration was 8.7 ± 1.0 h/night at 6 weeks post-treatment. More sedentary behavior was longitudinally associated with a shorter sleep duration (β = -0.28; 95%CI = -0.35, -0.21). More standing was associated with a shorter sleep duration (β = -0.21; 95%CI = -0.25, -0.16), higher sleep variability (β = 0.29%; 95%CI = 0.03, 0.55), improved sleep quality (β = -0.24; 95%CI = -0.43, -0.04), and reduced insomnia symptoms (β = -2.00; 95%CI = -3.27, -0.72). More total physical activity was associated with a shorter sleep duration (β = -0.31; 95%CI = -0.41, -0.21) and higher sleep variability (β = 0.59%; 95%CI = 0.11, 1.10). More moderate-to-vigorous physical activity was associated with a shorter sleep duration (β = -0.04; 95%CI = -0.07, -0.00) and reduced insomnia symptoms (β = -1.74; 95%CI = -2.69, -0.79).ConclusionOur findings suggest that physical (in)activity and standing are relevant for sleep-related symptoms in CRC survivors. Future studies should examine whether substituting sedentary behavior with standing and/or physical activity may alleviate sleep-related symptoms in CRC survivors.

Keyword(s): Humans (MeSH) ; Sedentary Behavior (MeSH) ; Male (MeSH) ; Female (MeSH) ; Colorectal Neoplasms: complications (MeSH) ; Colorectal Neoplasms: therapy (MeSH) ; Colorectal Neoplasms: physiopathology (MeSH) ; Exercise: physiology (MeSH) ; Middle Aged (MeSH) ; Prospective Studies (MeSH) ; Longitudinal Studies (MeSH) ; Sleep Quality (MeSH) ; Aged (MeSH) ; Sleep: physiology (MeSH) ; Cancer Survivors: statistics & numerical data (MeSH) ; Surveys and Questionnaires (MeSH) ; Accelerometry (MeSH) ; Sleep Duration (MeSH) ; colorectal cancer survivorship ; nocturnal rest ; physical activity ; sedentary behavior ; sleep duration ; sleep quality

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Contributing Institute(s):

1. Bewegung, Krebsprävention und Survivorship (C110)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2025

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Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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