Journal Article

DKFZ-2025-02599

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Refining surveillance in Myxoid liposarcoma: long-term recurrence patterns and functional outcomes after surgery ± radiotherapy in 186 patients.

Roohani, S.DKFZ* ; Chung, P. W. M. ; Dickson, B. C. ; Ferguson, P. C. ; Griffin, A. M. ; Kirsch, D. G. ; Krcek, R. ; O'Sullivan, B. ; Shultz, D. B. ; Tsoi, K. M. ; Wong, P. ; Wunder, J. S. ; Catton, C. N.

2026
Elsevier Science Amsterdam [u.a.]

Abstract: To assess oncologic, functional outcomes, and recurrence patterns in a large cohort of prospectively collected patients with localized extremity/trunk myxoid liposarcoma with long-term follow-up.Analysis of 186 patients (1992-2025) treated with surgery ± perioperative radiotherapy. Data were drawn from prospective institutional registries with central pathology/radiology review.wound complications, late toxicity, functional scores, overall survival (OS), cancer-specific survival (CSS), and local (LR) and distant metastatic recurrence (DM).Median age was 44.5 years; median follow-up 77 months. All had surgery; 86.6 % received radiotherapy (73.7 % preoperatively). Wound complications occurred in 33.3 %. Late ≥ Grade 2 toxicities: skin (7.5 %), subcutaneous fibrosis (14.5 %), joint stiffness (2.2 %), edema (9.1 %). Functional scores at last follow-up: median TESS: 97 (mean 91.3), MSTS-87: 35 (mean 33.1), MSTS-93: 100 (mean 94.7). LR: 3 cases (1.6 %, 5-year cumulative incidence: 1.4 %). DM: 31 patients (16.7 %), involving 40 sites (42.5 % soft tissue, 22.5 % lung, 17.5 % bone, 7.5 % liver, 5 % lymph nodes). Cumulative incidence of DM: 1-year 0.6 %, 5-year 10.8 %, 10-year 23.4 %. CSS was 100 %, 96.4 %, and 80 % at 1, 5, and 10 years, respectively. OS was 98.8 %, 92 %, and 74.2 % at the same time points.Local control was high, and long-term function were favorable. Distant recurrences were more frequent, occurred at a constant rate beyond 5 years, without plateau, often involved extra-pulmonary sites, and drove late cancer-related mortality. These findings support the consideration of continued annual follow-up through at least 10 years, with imaging of pulmonary and extra-pulmonary sites to adequately capture the full spectrum of metastatic risk.

Keyword(s): Cohort study ; Distant failure ; Extremities ; MSTS ; RTOG ; Soft tissue sarcoma ; TESS ; Toxicity ; Trunk wall

Note: Volume 214, January 2026, 111275

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Berlin (BE01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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